This is an universal question that torments the mind. However it takes a special place in the mind of someone who prays or meditates or does good deeds. How can you comfort the mind? How does your logic process it?
Do you use theory of karma? Bemoan and accept it as your fate? Or those who do believe in religion may just simply turn to drugs and alcohol
In intense situations only a guru who knows the reason of why we suffer, can help. Talking discussion is NOT the way to support or cure the mind. Meditation can help but with intense pain the mind loses faith and is unable to meditate. This is why a guru is needed
Such Guru play a tremendous role. However they can help only some in the spiritual path but many is taking their pain away
These are general guidelines. I should stop here
Bhavin